Review The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge
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منابع مشابه
The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge
The Cancer Genome Atlas (TCGA) is a public funded project that aims to catalogue and discover major cancer-causing genomic alterations to create a comprehensive "atlas" of cancer genomic profiles. So far, TCGA researchers have analysed large cohorts of over 30 human tumours through large-scale genome sequencing and integrated multi-dimensional analyses. Studies of individual cancer types, as we...
متن کاملInsights into the Genetic Basis of the Renal Cell Carcinomas from The Cancer Genome Atlas (TCGA)
The renal cell carcinomas, clear cell, papillary, and chromophobe, have recently undergone an unmatched genomic characterization by The Cancer Genome Atlas (TCGA). This analysis has revealed new insights into each of these malignancies, and underscores the unique biology of clear cell, papillary, and chromophobe renal cell carcinoma. Themes that have emerged include distinct mechanisms of metab...
متن کاملRegulation of Pharmacogene Expression by microRNA in The Cancer Genome Atlas (TCGA) Research Network
Individual differences in drug responses are associated with genetic and epigenetic variability of pharmacogene expression. We aimed to identify the relevant miRNAs which regulate pharmacogenes associated with drug responses. The miRNA and mRNA expression profiles derived from data for normal and solid tumor tissues in The Cancer Genome Atlas (TCGA) Research Network. Predicted miRNAs targeted t...
متن کاملPreviously defined 53 immune gene panel predicts melanoma survival using The Cancer Genome Atlas (TCGA)
Methods TCGA dataset for melanoma (n=407) was screened to determine two extreme groups of patients – alive at least 4 years (n=67) and dead within 2 years from diagnosis (n=59). Genome wide differential expression analysis was performed between the two groups to study our prognostic signature. We used gene set enrichment analysis (GSEA) to evaluate the activation status of the 53 gene panel as ...
متن کاملMolecular characteristics of non-small cell lung cancer with reduced CHFR expression in The Cancer Genome Atlas (TCGA) project.
BACKGROUND CHFR expression has previously been established as a powerful predictor for response to taxane based first-line chemotherapy in non-small cell lung cancer. It is currently unknown however, if reduced CHFR expression correlates with certain molecular subtypes of lung cancer. PURPOSE In order to determine which patients may benefit from CHFR biomarker testing we conducted the present...
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ژورنال
عنوان ژورنال: Współczesna Onkologia
سال: 2015
ISSN: 1428-2526
DOI: 10.5114/wo.2014.47136